COX-2-IN-23 (compound A10) is a potent bothAChEandHDACinhibitor withIC₅₀values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research^[1].

COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC₅₀values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively^[1].
COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%)^[1].
COX-2-IN-23 (compound A10) exhibits Cu²⁺chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity^[1].

478.97

C₂₆H₂₇ClN₄O₃

2414053-06-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.