Snail/HDAC-IN-1

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Snail/HDAC-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2415281-52-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Snail/HDAC-IN-1是一种有效的Snail/HDAC双靶点抑制剂。Snail/HDAC-IN-1 对 HDAC1 有较强的抑制活性，IC₅₀为0.405 μM，对 Snail 有较强的抑制作用，K_d为 0.18 μM。Snail/HDAC-IN-1 增加 HCT-116 细胞中的组蛋白 H4 乙酰化，并降低 Snail 蛋白的表达，从而诱导细胞凋亡 (apoptosis)。

生物活性

Snail/HDAC-IN-1 is a potentSnail/HDACdual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity againstHDAC1with an IC₅₀of 0.405 μM and potent inhibition against Snail with a K_dof 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cellapoptosis^[1].

IC₅₀& Target^[1]

HDAC1

0.405 μM (IC₅₀)

Snail

0.18 μM (Kd)

体外研究
(In Vitro)

Snail/HDAC-IN-1 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC₅₀of 0.0751 μM. Snail/HDAC-IN-1 shows a good inhibitory effect on NCI–H522 (GI₅₀=0.0488 μM), MDA-MB-435 (GI₅₀=0.0361 μM), and MCF7 (GI₅₀=0.0518 μM)^[1].

分子量

488.54

Formula

C₂₄H₂₁FN₈OS

CAS 号

2415281-52-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.