HDAC/HSP90-IN-3

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HDAC/HSP90-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2700035-54-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HDAC/HSP90-IN-3 (化合物 J5) 是一种有效的选择性真菌Hsp90和HDAC双重抑制剂，其IC₅₀值分别为 0.83 和 0.91 μM。HDAC/HSP90-IN-3 对耐唑白色念珠菌具有抗真菌活性。HDAC/HSP90-IN-3 可抑制重要毒力因子，下调耐药基因ERG11和CDR1。

生物活性

HDAC/HSP90-IN-3 (compound J5) is a potent and selectivefungalHsp90andHDACdual inhibitor, withIC₅₀values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistantC. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1^[1].

IC₅₀& Target

HSP90

0.83 μM (IC₅₀, fungal Hsp90)

HDAC

0.91 μM (IC₅₀, fungal HDACs)

human HDAC

3.0 μM (IC₅₀, human HDACs)

HSP90

19.52 μM (IC₅₀, human Hsp90)

体外研究
(In Vitro)

HDAC/HSP90-IN-3 (compound J5) significantly down-regulates the adherence-related genes (such as ALS3, HWP1, EAP1, BCR1), and down-regulates the expression of ERG11 and CDR1^[1].

分子量

511.57

Formula

C₂₆H₃₃N₅O₆

CAS 号

2700035-54-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.