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Morin hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Morin hydrate图片
CAS NO:6202-27-3
包装:500mg
市场价:347元

产品介绍
Morin hydrate 是一种植物来源的类黄酮,具有低抗氧化活性。
Cas No.6202-27-3
别名桑色素.桑黄素
化学名2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one hydrate
Canonical SMILESOC1=C(C(C(O)=C2)=CC=C2O)OC3=CC(O)=CC(O)=C3C1=O.O
分子式C15H10O7.H2O
分子量320.25
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Morin hydrate is a plant flavonoid extracted from yellow Brazil wood with anti-oxidant properties. Previous studies have shown that morin hydrate could protect cells against oxygen radical damage.

In vitro: Morin hydrate at 75-100 μM protected against the oxidation of low density lipoprotein (LDL) induced by free radicals [1]. Morin hydrate at 100 μM concentration effectively inhibited Cu2+-induced oxidation of human LDL [2]. In cultured rat glomerular mesangial cells attacked by oxyradicals, the survival time of the cells was doubled with using morin hydrate [3]. 0.25 – 2.0 mM morin prolonged the survival of rat hepatocytes against free radical damage triggered by xanthine oxidase-hypoxanthine [4]. Morin hydrate could inhibit the amyloid formation by islet amyloid polypeptide and disaggregated amyloid fibers [5].

In vivo: In a 80 min ischemia rat model, treatment of morin at 2.5, 5.0 and 10 μmol/Kg reduced liver necrosis by 51.48 ± 9.94%, 66.55 ± 2.18%, and 79.37 ± 11.03%, respectively [3].

References:
[1].Wu T W, Fung K P, Wu J, et al. Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein[J]. Life sciences, 1995, 58(2): PL17-PL22.
[2].Wu T W, Fung K P, Yang C C, et al. Antioxidation of human low density lipoprotein by horin hydrate[J]. Life sciences, 1995, 57(3): PL51-PL56.
[3].Zeng L H, Fung K P, Wu T W. Morin hydrate protects cultured rat glomerular mesangial cells against oxyradical damage[J]. Life sciences, 1994, 55(18): PL351-PL357.
[4].Wu T W, Zeng L H, Wu J, et al. Morin hydrate is a plant-derived and antioxidant-based hepatoprotector[J]. Life sciences, 1993, 53(13): PL213-PL218.
[5].Noor H, Cao P, Raleigh D P. Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers[J]. Protein Science, 2012, 21(3): 373-382.