4'-O-methyl Quercetin (4'-O-Methyl Quercetin) 是槲皮素的天然类黄酮衍生物，具有抗氧化和抗炎作用。
| Cas No. | 603-61-2 |
| 别名 | 柽柳黄素,4'-O-Methyl Quercetin |
| Canonical SMILES | OC1=CC(O)=C(C(C(O)=C(C2=CC=C(OC)C(O)=C2)O3)=O)C3=C1 |
| 分子式 | C16H12O7 |
| 分子量 | 316.3 |
| 溶解度 | DMSO: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 4'-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4'-O-methyl Quercetin is a major metabolite of quercetin that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4'-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4'-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose). |
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