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β-Muricholic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
β-Muricholic Acid图片
CAS NO:2393-59-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A murine-specific primary bile acid
Cas No.2393-59-1
别名Β-鼠胆酸,5β-Cholanic Acid-3α,6β,7β-triol, β-MCA
化学名(5β)-3α,6β,7β-trihydroxy-cholan-24-oic acid
Canonical SMILESOC(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O
分子式C24H40O5
分子量408.6
溶解度20mg/ml in ethanol & DMSO, 30mg/ml in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

Reference:
[1]. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem. 66(3), 507-514 (1976).
[2]. Wahlstrom, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).
[3]. Fujino, Y., Nakayama, K., Yoshimura, K., et al. Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acid. Jpn. J. Pharmacol. 46(4), 421-423 (1988).
[4]. Wang, D.Q.-H., and Tazuma, S. Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J. Lipid. Res. 43(11), 1960-1968 (2002).