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DL-Mevalonolactone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DL-Mevalonolactone图片
CAS NO:674-26-0
包装与价格：
包装价格(元)
250mg电议
500mg电议
1g电议

产品介绍
DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) 是甲羟戊酸的 δ-内酯形式，是甲羟戊酸途径的前体。
Cas No.674-26-0
别名甲瓦龙酸内酯,(±)-Mevalonolactone; Mevalolactone
Canonical SMILESO=C1CC(O)(C)CCO1
分子式C6H10O3
分子量130.1
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

References:
[1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.
[2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.