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N-Ethylmaleimide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-Ethylmaleimide图片
CAS NO:128-53-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议

产品介绍
N-乙基马来酰亚胺（NEM）来源于马来酸，它可以烷基化游离的巯基。
Cas No.128-53-0
别名N-乙基马来酰亚胺; NEM
Canonical SMILESO=C(C=C1)N(CC)C1=O
分子式C6H7NO2
分子量125.13
溶解度DMSO : 50 mg/mL (399.58 mM) Water : 50 mg/mL (399.58 mM), Ethanol : 12.5 mg/mL (99.90 mM)
储存条件Store at 4℃, sealed storage, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

Reference:
[1]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9.
[2]. Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15.
[3]. Choo YS, et al. Detection of protein ubiquitination. J Vis Exp. 2009;(30):1293. Published 2009 Aug 19. doi:10.3791/1293