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K34c
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K34c图片
CAS NO:939769-93-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
K34c 是一种有效的、选择性α5β1 integrin拮抗剂。 K34c 可用于胶质母细胞瘤研究。
生物活性

K34c is a potent and selectiveα5β1integrinantagonist. K34c can be used for glioblastoma research[1].

IC50& Target[1]

α5β1

 

体外研究
(In Vitro)

K34c (20 μM; 24 or 48 h) significantly induces U87MG cells apoptosis in combination with 1 μMEllipticine(HY-15753)[1].
K34c (20 μM; 48 h) decreases significantlyTemozolomide(HY-17364)-induced senescence in cells transfected with control non targeting siRNA without affecting significantly the residual senescence of cells transfected with siRNA specific for p53[1].
K34c (20 μM; 24 h) modulates the p53 pathway.

Apoptosis Analysis[1]

Cell Line:U87MG cells
Concentration:20 μM
Incubation Time:24 or 48 h
Result:Induced apoptosis, led to a significant increase in apoptotic cell death measured by the population of sub-G1 cells in combination with 1 μMEllipticine(HY-15753).

Western Blot Analysis[1]

Cell Line:U87MG cells
Concentration:20 μM
Incubation Time:24 h
Result:DecreasedEllipticine(HY-15753)- andTemozolomide(HY-17364)-induced activation of p53.
分子量

447.53

Formula

C26H29N3O4

CAS 号

939769-93-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.