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ATN-161
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ATN-161图片
CAS NO:262438-43-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ATN-161 (Ac-PHSCN-NH2)是一由纤连蛋白的协同区域衍生出的五氨基酸短肽;具有抗肿瘤活性的β整合素拮抗剂。
生物活性

ATN-161 is a novelintegrinα5β1antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.

IC50& Target

Integrin α5β1[1]

体外研究
(In Vitro)

The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03)[1]. ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P<0.001 vs. VEGF group)[2].

体内研究
(In Vivo)

The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density[1]. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564[2].

Clinical Trial
分子量

597.64

Formula

C23H35N9O8S

CAS 号

262438-43-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.