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Kazinol B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kazinol B图片
CAS NO:99624-27-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
小构树醇B
产品介绍
Kazinol B 是一种带有二甲基吡喃环的异戊二烯化黄烷,是一氧化氮 (NO) 生成的抑制剂。Kazinol B 通过胰岛素-Akt 信号通路和 AMPK 激活增强葡萄糖摄取,从而改善胰岛素敏感性。Kazinol B 具有用于糖尿病研究的潜力。
生物活性

Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor ofnitric oxide (NO)production. Kazinol B improvesinsulinsensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway andAMPKactivation. Kazinol B has the potential for diabetes mellitus research[1][2].

IC50& Target[1]

AMPK

 

体外研究
(In Vitro)

Kazinol B (2, 10 and 20 μM; 72 hours) shows no toxicity to adipocytes in 3T3-L1 cells[1].
Kazinol B (2-20 μM; 72 hours) dose-dependently increases lipid accumulation by 2.4-fold (at 20 μM) treatment as compared with MDI-treated cells[1].
Kazinol B (2-20 μM; 5 days) dose-dependently increases PPARγ and C/EBPα protein and mRNA levels in MDI-treated 3T3-L1 adipocytes. Kazinol B increases the mRNA level of adiponectin in a dose-dependent manner[1].
Kazinol B (2-20 μM; 24 hours) increases the retained 2′NBDG-fluorescence in cells in a dose-dependent manner in differentiated 3T3-L1 adipocytes and C2C12 myoblasts. Kazinol B dependently increases the MDI-stimulated GLUT4 mRNA level up to 4.7-fold as compared with MDI-only treated cells[1].
Kazinol B (10-20 μM; pre-treated for 1 h followed by 1 h insulin) dose-dependently increases insulin-dependent Akt phosphorylation. Kazinol B alone strongly induces Akt phosphorylation compared with untreated cells. Kazinol B also increased insulin-stimulated AMPK phosphorylation[1].
Kazinol B (6.25, 12.5, 25, 50 μM; 18 hours) dose-dependently reduces amounts of iNOS protein in macrophages (RAW 264.7 cells) activated by LPS (1 ug/mL)[2].

分子量

392.49

Formula

C25H28O4

CAS 号

99624-27-8

中文名称

小构树醇B

结构分类
  • Phenols
  • Polyphenols
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.