AMPK activator 10 是一种具有口服活性的AMPK激活剂,通过细胞 ELISA 检测,EC150为 44.3 nM。AMPK activator 10 增加 ACC 的磷酸化水平。AMPK activator 10 具有降糖作用。
生物活性 | AMPK activator10 is an orally active, potentAMPKactivator withEC150of 44.3 nM by cell-ELISA.AMPK activator10 increases the phosphorylation levels of ACC.AMPK activator10 exhibits a glucose lowering effect[1]. |
IC50& Target[1] | |
体内研究 (In Vivo) | AMPK activator 10 (化合物14d; 0.3, 1, 3 mg/kg; 口服灌胃; 一天2次; 21 天) 表现出降糖作用[1]。 AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; 口服灌胃; 单剂量) 以剂量依赖性方式导致 ACC 的磷酸化水平升高,ACC 是 AMPK 的下游靶分子[1]。 AMPK activator 10 (0.5 mg/kg 静脉注射或 1.0 mg/kg 口服灌胃) 在大鼠中的 CL 为 9.02 mL/minokg,Cmax为 65.4 ng/mL,AUC 为 347 ng oh/mL[1]。
Animal Model: | KKAy mice[1] | Dosage: | 0.3, 1, 3 mg/kg | Administration: | Orally; bid; for 21 days | Result: | Exhibited a glucose lowering effect. The increase in hemoglobin A1c (ΔHbA1c) between day 0 and day 21 was dose-dependently suppressed in the 14d dosed group. |
Animal Model: | Rats[1] | Dosage: | 0.5 mg/kg by iv or 1.0 mg/kg by po | Administration: | IV or po | Result: | Had a CL of 9.02 mL/minokg, a Cmaxof 65.4 ng/mL and an AUC of 347 ngoh/mL. |
|
分子量 | |
Formula | |
CAS 号 | |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |