CAS NO: | 890643-16-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | DC-05 is aDNA methyltransferase1 (DNMT1) inhibitor, with anIC50and aKdof 10.3 μM and 1.09 μM, respectively. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50and a Kdof 10.3 μM and 1.09 μM, respectively. DC-05 shows less potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM). DC-05 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h[1]. | ||||||||||||||||
分子量 | 383.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H25N3O | ||||||||||||||||
CAS 号 | 890643-16-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(260.76 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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