YF-2 hydrochloride is a highly selective, blood-brain-barrier permeablehistone acetyltransferaseactivator, acetylates H3 in the hippocampus, withEC₅₀s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect onHDAC. Anti-cancer and anti-Alzheimer's disease^[1].

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells^[1].

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice^[1].

467.31

C₂₀H₂₃Cl₂F₃N₂O₃

1312005-62-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.