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YF-2 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YF-2 hydrochloride图片
CAS NO:1312005-62-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
YF-2 hydrochloride 是一种高度选择性、可透过血脑屏障的组蛋白乙酰转移酶 (histone acetyltransferase) 激动剂,能够在海马区乙酰化 H3,对 CBP,PCAF 和 GCN5 的EC50值分别为 2.75 μM,29.04 μM 和 49.31 μM,对 HDAC 无作用。具有抗肿瘤和抗阿尔滋海默症的活性。
生物活性

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeablehistone acetyltransferaseactivator, acetylates H3 in the hippocampus, withEC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect onHDAC. Anti-cancer and anti-Alzheimer's disease[1].

IC50& Target[1]

GCN5

49.31 μM (EC50)

体外研究
(In Vitro)

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

体内研究
(In Vivo)

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

分子量

467.31

Formula

C20H23Cl2F3N2O3

CAS 号

1312005-62-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.