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Eicosapentaenoic Acid sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eicosapentaenoic Acid sodium图片
CAS NO:73167-03-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
二十碳五烯酸钠盐
EPA sodium
Timnodonic acid sodium
产品介绍
Eicosapentaenoic Acid (EPA) sodium 是一种具有口服活性的 ω-3 长链多不饱和脂肪酸 (ω-3 LC-PUFAs)。Eicosapentaenoic Acid sodium 具有促进肿瘤抑制基因 CCAAT/增强子结合蛋白δ (C/EBPδ) 重新表达的 DNA 去甲基化作用。Eicosapentaenoic Acid sodium 通过 H-RAS 内含子 1 CpG 岛去甲基化激活 U937 白血病细胞中的 RAS/ERK/C/EBPβ 途径。Eicosapentaenoic Acid sodium 能促进血管平滑肌细胞的松弛和血管舒张。
生物活性

Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway throughH-Rasintron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

IC50& Target[1][2][3]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 μM; 24 h) sodium treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1].
Eicosapentaenoic Acid (100 μM; 1, 3, 24 h) sodium causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid sodium[1].

Clinical Trial
分子量

324.43

Formula

C20H29NaO2

CAS 号

73167-03-0

中文名称

二十碳五烯酸钠盐

结构分类
  • Ketones, Aldehydes, Acids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.