包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | GSK-J1 lithium salt is a potent inhibitor ofH3K27me3/me2-demethylases JMJD3/KDM6BandUTX/KDM6A, withIC50of 60 nM towards KDM6B. |
IC50& Target | IC50: 60 nM (KDM6B)[2] |
体外研究 (In Vitro) | GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC50of 11 μM and 94 μM, respectively[3]. |
分子量 | 395.38 |
Formula | C22H22LiN5O2 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |