您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > GSK-J1 lithium salt
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
GSK-J1 lithium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK-J1 lithium salt图片
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
GSK-J1 lithium salt 是一种有效的H3K27me3/me2-demethylases JMJD3/KDM6BUTX/KDM6A的抑制剂,对 KDM6B 的IC50值为 60 nM。
生物活性

GSK-J1 lithium salt is a potent inhibitor ofH3K27me3/me2-demethylases JMJD3/KDM6BandUTX/KDM6A, withIC50of 60 nM towards KDM6B.

IC50& Target

IC50: 60 nM (KDM6B)[2]

体外研究
(In Vitro)

GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC50of 11 μM and 94 μM, respectively[3].

分子量

395.38

Formula

C22H22LiN5O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.