CAS NO: | 1990504-34-1 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
生物活性 | Bomedemstat (IMG-7289) is an orally active and irreversiblelysine-specific demethylase 1(LSD1) inhibitor. Bomedemstat can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat shows anti-cancer activities, inhibitscancercell proliferation and inducesapoptosis[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | Bomedemstat selectively inhibits proliferation and induces apoptosis ofJak2V617Fcells by concomitantly increasing expression and methylation of p53[1]. Apoptosis Analysis[1]
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体内研究 (In Vivo) | Bomedemstat treatment (oral gavage; 45 mg/kg; once daily; 56 d) normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis[1].
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Clinical Trial | |||||||||||||||||
分子量 | 519.61 | ||||||||||||||||
性状 | Oil | ||||||||||||||||
Formula | C28H34FN7O2 | ||||||||||||||||
CAS 号 | 1990504-34-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(192.45 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |