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INCB059872
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
INCB059872图片
CAS NO:1802909-49-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
INCB059872是一种有效、具有口服活性,选择性和不可逆的赖氨酸特异性去甲基化酶1 (LSD1) 抑制剂。INCB059872可用于髓系白血病的研究。
生物活性

INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 can be used for the research of myeloid leukemia[1].

IC50& Target

KDM1/LSD1

 

体外研究
(In Vitro)

INCB059872 (25 nM; 48 hours; 293T cells) increases enhancer activity and gene expression[1].
INCB059872 (25 nM; 24 hours; THP-1 cells) makes THP-1 show a growth defect within one cell doubling time or approximately 3 days. INCB059872 (THP-1 cells) regulates PRO-seq analysis identifies genes and enhancers[1].

Western Blot Analysis[1]

Cell Line:293T cells
Concentration:250 nM
Incubation Time:48 hours
Result:Increased enhancer activity and gene expression.
体内研究
(In Vivo)

INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) makes single-cell RNA-seq revealing changes in bone marrow progenitor populations[1].

Animal Model:Mice[1]
Dosage:10 mg/kg
Administration:P.o.; 0, 4, or 6 days
Result:Single-cell RNA-seq revealed changes in bone marrow progenitor populations.
Clinical Trial
分子量

386.53

Formula

C23H34N2O3

CAS 号

1802909-49-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.