RJW100

立即咨询

RJW100

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1276664-20-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

RJW100 是一种有效的肝受体同源物 1 (LRH-1，NR5A2) 和类固醇生成因子-1 (SF-1，NR5A1) 激动剂，pEC₅₀分别为 6.6 和 7.5。RJW100 还可有效激活miR-200c (miRNA-200c, microRNA-200c)启动子。

生物活性

RJW100 is a potentliver receptor homolog 1 (LRH-1, NR5A2)andsteroidogenic factor-1 (SF-1, NR5A1)agonist withpEC₅₀s of 6.6 and 7.5, respectively^[1]. RJW100 also causes strong activation of themiR-200c (miRNA-200c, microRNA-200c) promoter^[2].

IC₅₀& Target

pEC50: 6.6 (LRH-1) and 7.5 (SF-1)^[1]

体外研究
(In Vitro)

RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 μM^[1].
RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 μM^[1].
Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 μM) binding^[1].
RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins^[2].

RT-PCR^[1]

Cell Line:	HEK293 cells
Concentration:	1 μM, 5 μM, 10 μM
Incubation Time:	24 hours
Result:	Induced a significant dose-dependent increase in SHP transcripts beginning at 5 μM.

分子量

386.57

Formula

C₂₈H₃₄O

CAS 号

1276664-20-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.