CAS NO: | 1214726-89-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | AS2521780 is a novelPKCθselective inhibitor with anIC50of 0.48 nM. | ||||
IC50& Target |
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体外研究 (In Vitro) | AS2521780 exerts potent inhibition of recombinant human PKCθ enzyme activity (IC50=0.48 nM), which is more than 30-fold higher than that of other PKC isoforms. Further, AS2521780 exerts little or no inhibition on other protein kinases. AS2521780 suppresses CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and proliferation of human primary T cells. AS2521780 also suppresses concanavalin A-induced cytokine production by rat splenocytes and monkey peripheral blood mononuclear cells with similar potency[1]. | ||||
体内研究 (In Vivo) | AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1]. | ||||
分子量 | 547.76 | ||||
Formula | C30H41N7OS | ||||
CAS 号 | 1214726-89-2 | ||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |