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AS2521780
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AS2521780图片
CAS NO:1214726-89-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
AS2521780是新颖的PKCθ选择性抑制剂,IC50值为0.48 nM。
生物活性

AS2521780 is a novelPKCθselective inhibitor with anIC50of 0.48 nM.

IC50& Target

PKCθ

0.48 nM (IC50)

PKCε

18 nM (IC50)

PKCα

160 nM (IC50)

PKCδ

160 nM (IC50)

体外研究
(In Vitro)

AS2521780 exerts potent inhibition of recombinant human PKCθ enzyme activity (IC50=0.48 nM), which is more than 30-fold higher than that of other PKC isoforms. Further, AS2521780 exerts little or no inhibition on other protein kinases. AS2521780 suppresses CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and proliferation of human primary T cells. AS2521780 also suppresses concanavalin A-induced cytokine production by rat splenocytes and monkey peripheral blood mononuclear cells with similar potency[1].

体内研究
(In Vivo)

AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1].

分子量

547.76

Formula

C30H41N7OS

CAS 号

1214726-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.