CAS NO: | 1221964-50-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | PS315, a derivative of PS48 (HY-15967), is an allostericPKCinhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs ofPKCζ(IC50=10 μM) andPKCη(IC50=30 μM). PS315 has anti-cancer activity[1]. | ||
IC50& Target[1] |
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体外研究 (In Vitro) | Preincubation of U937 cells with 5 μM PS315 inhibits TNF-α induced NF-κB activation by 74%, whereas complete inhibition is observed with 10 μM PS315[1]. | ||
分子量 | 362.85 | ||
Formula | C23H19ClO2 | ||
CAS 号 | 1221964-50-6 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |