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Bryostatin 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bryostatin 1图片
CAS NO:83314-01-6
包装:10 μg
市场价:5200元

产品名称
苔藓抑素1
产品介绍
Bryostatin 1 是一种天然的大环内酯类化合物,从苔藓虫Bugula neritina中分离出来,也是一种有效的中枢神经系统 (CNS) 渗透性的PKC调节剂。Bryostatin 1 以Ki值为 8.07 nM 和 0.45 nM 分别结合到分离的Munc13-1的 C1 域和全长的Munc13-1蛋白。Bryostatin 1 具有抗癌,抗炎,神经保护,抗HIV-1感染的特性。
生物活性

Bryostatin 1 is a naturalmacrolideisolated from the bryozoanBugula neritinaand is a potent and central nervous system (CNS)-permeablePKCmodulator. Bryostatin 1 binds to the isolated C1 domain ofMunc13-1and the full-lengthMunc13-1protein withKis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1infectionproperties[1][2][3][4].

IC50& Target

HIV-1

 

体外研究
(In Vitro)

Bryostatin 1 (1 μM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation[1].
The increased level of expression of Munc13-1 following a 24 h incubation with Bryostatin 1 in both HT22 and primary mouse hippocampal cells is observed[1].
Bryostatin 1 can also affect the immune system by modulating dendritic cells (DCs) via toll-like receptor 4 (TLR4) through the MyD88-independent pathway, which favors an anti-inflammatory environment by inducing a type 2 phenotype that promotes the differentiation of CD4+T-helper (Th) lymphocytes into Th2 versus Th1 effector cells[2].

Western Blot Analysis[1]

Cell Line:HT22 cells
Concentration:1 μM
Incubation Time:5 minutes
Result:Caused Munc13-1 to transfer to the membrane fraction.
体内研究
(In Vivo)

Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE[2].

Animal Model:Female C57BL/6J mice (8-12-week-old) with MOG35-55[2]
Dosage:30 μg/kg
Administration:Intraperitoneal injection; 3 d per week; for 2 weeks
Result:Abolished the onset of experimental autoimmune encephalomyelitis (EAE).
Clinical Trial
分子量

905.03

性状

Solid

Formula

C47H68O17

CAS 号

83314-01-6

中文名称

苔藓抑素1

结构分类
  • Antibiotics
  • Macrolide Antibiotics
来源

Bugula neritina

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month