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Psychosine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Psychosine图片
CAS NO:2238-90-6
包装:5mg
市场价:5900元

产品名称
Galactosylsphingosine
产品介绍
Psychosine (Galactosylsphingosine) 是半乳糖脑苷脂酶 (GALC) 酶的底物,是 Krabbe 病的潜在生物标志物。Psychosine 是一种高度细胞毒性的脂质,能够在多种细胞类型中诱导细胞死亡,且有部分是通过细胞凋亡 (apoptosis) 导致的细胞死亡。Psychosine 还是一种PKC抑制剂。
生物活性

Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part viaapoptosis. Psychosine also is an inhibitor ofPKC[1].

IC50& Target[2]

PKC

 

体外研究
(In Vitro)

Psychosine, is a substrate of the GALC enzyme that shows promise to aid in the diagnosis and follow-up of at-risk infants identified through newborn screening (NBS)[1]. Psychosine induces pleiotropic effects, including dysfunctions in several cellular pathways[2].

Cell Viability Assay[2]

Cell Line:Oligodendrocyte cells, M03.13
Concentration:10, 20, and 40 μM
Incubation Time:24 hours
Result:Caused cell death at least in part via apoptosis.
分子量

461.63

性状

Solid

Formula

C24H47NO7

CAS 号

2238-90-6

中文名称

鞘氨醇半乳糖苷;半乳糖基鞘氨醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month