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TAS-301
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAS-301图片
CAS NO:193620-69-8
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
TAS-301 是一种平滑肌迁移和增殖抑制剂,能够抑制 PDGF 诱导的PKC的活化。
生物活性

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibitsPKCactivation induced byPDGF.

IC50& Target[1]

PKC

 

体外研究
(In Vitro)

TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca2+influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively[1]. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM[2].

体内研究
(In Vivo)

TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury[2].

分子量

357.40

性状

Solid

Formula

C23H19NO3

CAS 号

193620-69-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 38 mg/mL(106.32 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.7980 mL13.9899 mL27.9799 mL
5 mM0.5596 mL2.7980 mL5.5960 mL
10 mM0.2798 mL1.3990 mL2.7980 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。