CAS NO: | 193620-69-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibitsPKCactivation induced byPDGF. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca2+influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively[1]. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM[2]. | ||||||||||||||||
体内研究 (In Vivo) | TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury[2]. | ||||||||||||||||
分子量 | 357.40 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H19NO3 | ||||||||||||||||
CAS 号 | 193620-69-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 38 mg/mL(106.32 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |