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ML-346
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ML-346图片
CAS NO:100872-83-1
包装与价格：
包装价格(元)
10mM 1 mL in DMSO电议
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
ML-346 是 Hsp70 表达和 HSF-1 活性的激活剂，对 Hsp70 的 EC50 为 4.6 μM。 ML-346 在构象疾病模型中恢复蛋白质折叠，没有明显的细胞毒性或缺乏特异性。 ML-346 诱导热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加，包括 Hsp70、Hsp40 和 Hsp27 等伴侣蛋白。
Cas No.100872-83-1
化学名5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione
Canonical SMILESO=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=C(OC)C=C2)=O
分子式C14H12N2O4
分子量272.3
溶解度0.5mg/mL in ethanol, 30mg/mL in DMSO, or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML-346 is an activator of the heat shock response that induces the expression of the heat shock proteins HSP70, HSP40, and HSP27.[1] It induces the expression of the oxidative stress response genes HO1, GCLM, and BiP in mouse embryonic fibroblasts (MEFs) and pretreatment protects cells from severe heat shock-induced death and H2O2-induced apoptosis. It promotes folding of metastable proteins in models of conformational disease, including cellular models of Huntingtin aggregation and cystic fibrosis. It reduces aggregate formation in PC12 cells expressing human Huntingtin exon 1 containing a 74 glutamine expansion when used at a concentration of 10 uM. It also corrects trafficking of cystic fibrosis transmembrane conductance regulator proteins bearing the F508 deletion (F508-CFTR) mutation carried by the majority of cystic fibrosis patients, leading to increased cell surface expression.

References
[1]. Calamini, B., Silva, M.C., Madoux, F., et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat. Chem. Biol. 8(2), 185-196 (2011).