| CAS NO: | 13488-22-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 13488-22-7 |
| 别名 | 5,8,11-十二烯酸,5,8,11-ETI |
| 化学名 | 5,8,11-eicosatriynoic acid |
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCC(=O)O |
| 分子式 | C20H28O2 |
| 分子量 | 300.4 |
| 溶解度 | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5,8,11-Eicosatriynoic Acid is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2]. Fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. In several tissues, these two enzymes act concomitantly on arachidonic acid [1]. 5,8,11-Eicosatriynoic Acid (5,8,11-ET) is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-Eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 L-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. In mouse mastocytoma cells, 5,8,11-Eicosatriynoic Acid inhibited A23187 and L-cysteine induced leukotriene C (LTC4) biosynthesis with ID50 value of 5 μM [2]. References: |
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