您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Sodium 4-Aminosalicylate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Sodium 4-Aminosalicylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sodium 4-Aminosalicylate图片
CAS NO:6018-19-5
规格:≥98%
包装与价格:
包装价格(元)
1g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)211.15
FormulaC7H7NO3.2H2O.Na
CAS No.6018-19-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 42 mg/mL (198.9 mM)
Water: <1 mg/mL
Ethanol: 42 mg/mL (198.9 mM)
SMILESO=C(O[Na])C1=C(O)C=C(N)C=C1.O.O
Synonyms4-Amino-salicylic acid sodium salt
实验参考方法
In Vitro

In vitro activity: 4-Aminosalicylate reacts promptly with DPPH, suggesting a potent radical scavenger activity. 4-Aminosalicylate exhibits peroxyl radical scavenging activity generated by the water-soluble 2,2'-azobis-(2-amidinopropane hydrochloride) azoinitiator of peroxyl radicals, as evidenced by the inhibition of cis-parinaric acid fluorescence decay or oxygen consumption. 4-Aminosalicylate rapidly scavenges peroxyl radicals in the aqueous phase, producing a concentration-dependent inhibition period similar to Trolox or cysteine, suggesting an antioxidant activity of chain-breaking type. [14C]4-Aminosalicylate transforms to a number of metabolites, among which we have characterized salicylate and gentisate, in activated mononuclear cells and activated granulocytes. 4-Aminosalicylate (0.65 mM) diminishes the lethal effect on cultured Chinese hamster ovary cells of adding either superoxide radical or hydrogen peroxide. Aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner via a pathway involving inositol 1,4,5-trisphosphate generation, calcium fluxes, and Gi/Go in cultured mouse peritoneal macrophages. 4-aminosalicylate (20 mM) increases the levels of inositol 1,4,5-trisphosphate by 260% after treatment of macrophages. 4-aminosalicylate (5 mM) potentiates the activation of PLD by protein kinase C in cultured mouse peritoneal macrophages.

In Vivo4-aminosalicylate (7.5 mg/mL, regional perfusions) results in the appearance of N-acetyl-5-aminosalicylic acid in the intestinal lumen in the anesthetized rat.
Animal modelRat
Formulation & Dosage7.5 mg/mL, regional perfusions
References

Arch Biochem Biophys. 1994 Nov 15;315(1):161-9; Biochem Pharmacol. 1987 Aug 1;36(15):2467-72.