CAS NO: | 129029-23-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Ocaperidone is an effective antipsychotic agent, acting as a potent5-HT2anddopamine D2antagonist, and a5-HT1Aagonist, withKis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1and a2-adrenergic receptor, respectively, and a pEC50andpKiof 7.60 and 8.08 for h5-HT1A. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Ocaperidone has high affinify at 5-HT2and dopamine D2, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5HT2, a1-adrenergic, dopamine D2, histamine H1and a2-adrenergic, respectively[1]. Ocaperidone shows 5-HT1Areceptor agonist activity, with a pEC50and pKiof 7.60 and 8.08[2]. | ||||||||||||||||
体内研究 (In Vivo) | Ocaperidone shows a potent occupation of 5HT2receptor via in vivo binding in the frontal cortex of rats with an ED50of 0.04 mg/kg, and 0.1 4-0.1 6 mg/kg for D2receptor in the striatum and the nucleus accumbens[1]. Ocaperidone (R 79598) antagonizes dopamine D2and 5-HT2, and shows a a partial generalization to buspirone with an ED50of 0.163 mg/kg[3]. | ||||||||||||||||
分子量 | 420.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H25FN4O2 | ||||||||||||||||
CAS 号 | 129029-23-8 | ||||||||||||||||
中文名称 | 奥卡哌酮 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 16.67 mg/mL(39.65 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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