SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selectivedopamine D₁-like receptorantagonist withK_is of 0.2 nM and 0.3 nM for theD₁andD₅receptor, respectively. SCH-23390 maleate is a potent and high efficacyhuman 5-HT_2Creceptoragonist with aK_iof 9.3 nM. SCH-23390 maleate also binds with high affinity to the5-HT₂and5-HT_1Creceptors. SCH-23390 maleate inhibitsG protein-coupled inwardly rectifying potassium (GIRK) channelswith anIC₅₀of 268 nM^[1][2][3].

SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway^[4].

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D₁receptors in rodents, nonhuman primates, and humans^[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat^[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O₂conditions^[5].

403.86

C₂₁H₂₂ClNO₅

87134-87-0

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Please store the product under the recommended conditions in the Certificate of Analysis.