PNU-282987 (free base) is a potentα7 nicotinic acetylcholine receptor (nAChR)agonist with anEC₅₀of 154 nM. PNU-282987 (free base) is also a functional antagonist of the5-HT₃receptorwith anIC₅₀of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems^[1].

PNU-282987 (free base) (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a K_iof 27 nM^[1].
PNU-282987 has α7 nAChR agonist activity with an EC₅₀of 154 nM^[1].
PNU-282987 also has inhibition for the 5-HT₃receptor with an IC₅₀value of 4541nM^[1].

PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit^[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner^[1].

264.75

C₁₄H₁₇ClN₂O

711085-63-1

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Please store the product under the recommended conditions in the Certificate of Analysis.