CAS NO: | 666179-74-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Risperidone hydrochloride (R 64 766 hydrochloride)5-HT2receptorblocker,P-Glycoproteininhibitor and potentdopamineD2receptorantagonist, withKisof 4.8, 5.9 nM for 5-HT2Aand dopamineD2receptor, respectively. | |||
IC50& Target |
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体外研究 (In Vitro) | Risperidone is a serotonin 5-HT2receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2Aand dopamine D2receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs[3]. | |||
体内研究 (In Vivo) | In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner[4]. | |||
Clinical Trial | ||||
分子量 | 446.95 | |||
Formula | C23H28ClFN4O2 | |||
CAS 号 | 666179-74-4 | |||
中文名称 | 利哌酮盐酸盐 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |