| CAS NO: | 898235-65-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 898235-65-9 |
| 化学名 | N-phenyl-4-(2-quinolinylmethyl)-1-piperazinecarboxamide |
| Canonical SMILES | O=C(Nc1ccccc1)N1CCN(CC1)Cc1ccc2ccccc2n1 |
| 分子式 | C21H22N4O |
| 分子量 | 346.4 |
| 溶解度 | ≤0.3mg/ml in ethanol;2mg/ml in DMSO;3mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PF-622 is a potent, time-dependent, irreversible FAAH inhibitor [1]. Fatty acid amide hydrolase (FAAH), belongs to a member of an unusual class of serine hydrolases, is an integral membrane enzyme involved in regulating the fatty acid amide family of lipid transmitters. Genetic or pharmacological inactivation of FAAH leads to elevated endogenous levels of fatty acid amides with analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes. The FAAH is an attractive drug target for the treatment of pain [1]. In vitro: PF-622 inhibited the activity of FAAH in a time-dependent manner with the IC50 values of 0.99 and 0.033 μM in human recombinant FAAH for 5 and 60 minutes, respectively [1]. In various human and murine tissue proteome samples, PF-622 showed highly selectivity for FAAH in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM [1]. PF-622 at 1 μM decreased IL-2 production in both healthy subjects and in HCV patients [2]. References: |
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