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(+)-Norfenfluramine hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(+)-Norfenfluramine hydrochloride图片
CAS NO:37936-89-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
(+)-Norfenfluramine hydrochloride 是 (+)-fenfluramine 的主要肝脏代谢物，是一种选择性的5-HT2B受体激动剂 (Ki: 11.2 nM)。(+)-Norfenfluramine hydrochloride 有效地刺激磷酸肌醇的水解并增加细胞内 Ca2+。(+)-Norfenfluramine hydrochloride 可用于原发性肺动脉高压和心脏瓣膜病的研究。
生物活性

(+)-Norfenfluramine hydrochloride, a major hepatic metabolite of (+)-fenfluramine, is a selective5-HT2Breceptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine hydrochloride potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine hydrochloride can be used for the research of primary pulmonary hypertension and valvular heart disease[1].

IC50& Target[1]

5-HT2BReceptor

11.2 nM (Ki)

5-HT2CReceptor

324 nM (Ki)

5-HT2AReceptor

1516 nM (Ki)

体外研究
(In Vitro)

(+)-Norfenfluramine (1 nM to 100 μM) hydrochloride contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats[1].
(+)-Norfenfluramine (1 and 10 μM, 3 min) hydrochloride induces contraction in aorta from tissues of normotensive and hypertensive rats[1].
(+)-Norfenfluramine (0-10 μM, 3 min) hydrochloride induces 5-HT release from rat hippocampal synaptosomes by Ca2+-dependent way[2].

体内研究
(In Vivo)

(+)-Norfenfluramine (1-300 μg/kg, i.v.) hydrochloride induces pressor response in conscious SHAM and DOCA-salt rats[1].
(+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) hydrochloride decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3].

Animal Model:Conscious SHAM and DOCA-salt rats[1].
Dosage:1-300 μg/kg
Administration:Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals.
Result:Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).
分子量

239.67

性状

Solid

Formula

C10H13ClF3N

CAS 号

37936-89-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 18.75 mg/mL(78.23 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.1724 mL20.8620 mL41.7240 mL
5 mM0.8345 mL4.1724 mL8.3448 mL
10 mM0.4172 mL2.0862 mL4.1724 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。