Alosetron (GR 68755) is a potent and highly selective serotonin5-HT3 receptorantagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects^[1][2].

Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis^[2].

294.35

C₁₇H₁₈N₄O

122852-42-0

阿洛司琼；洛曲尼斯；罗肠兴

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