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ML 145
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ML 145图片
CAS NO:1164500-72-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
ML 145 是一种选择性和竞争性的人 GPR35/CXCR8 拮抗剂，IC50/EC50 为 20.1 nM。
Cas No.1164500-72-4
化学名2-hydroxy-4-((Z)-(1-hydroxy-4-((Z)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)butylidene)amino)benzoic acid
Canonical SMILESCC(/C([H])=C(S1)/C(N(C1=S)CCC/C(O)=N/C2=CC(O)=C(C(O)=O)C=C2)=O)=C([H])\C3=CC=CC=C3
分子式C24H22N2O5S2
分子量482.57
溶解度<48.26mg/ml in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor[1]. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease[2].

References:
[1]. Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28.
[2]. Binti Mohd Amir NAS, et al. Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35. J Immunol. 2018 Jul 15;201(2):714-724.