CAS NO: | 739-71-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Trimipramine is a5-HT receptorantagonist, withpKibinding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1,hOCT2) withIC50values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy[1][2][3]. | ||||||||
IC50& Target |
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体外研究 (In Vitro) | Trimipramine displays much higher affinity for 5-HT2than for 5-HT1Creceptors[1]. | ||||||||
体内研究 (In Vivo) | Trimipramine (5 mg/kg/d; 14 d; chronic administration) acts as functions in rats:1. Increasing concentration of regional 5-HT. 5-HT is highest in the frontal cortex and the hippocampus, followed by the olfactory tubercles and the hypothalamus. 2. Decreasing the number of frontal cortex 5-HT2and striatal DA D2receptors. 3. Increasing in the brain regional level of monoamines and metabolites. thus indicates a greater synthesis rate for dopamine (DA) and 5-HT coinciding with an adaptive down regulation of 5-HT2and DA D2receptors[3].
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Clinical Trial | |||||||||
分子量 | 294.43 | ||||||||
Formula | C20H26N2 | ||||||||
CAS 号 | 739-71-9 | ||||||||
中文名称 | 曲米帕明 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |