ML 10302 hydrochloride

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CAS NO:

186826-17-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

ML 10302 hydrochloride 是一种高效、选择性的 5-HT₄受体 (5-HT₄receptor) 激动剂，其EC₅₀值为 4 nM。ML 10302 hydrochloride 对 5-HT₄的选择性结合作用比 5-HT₃至少高出 680 倍。

生物活性

ML 10302 hydrochloride is a potent and selective5-HT₄receptoragonist, with anEC₅₀of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over5-HT₃receptor in binding assay^[1]^[2].

IC₅₀& Target^[1]

5-HT₄Receptor

4 nM (EC₅₀)

5-HT₄Receptor

1.07 nM (Ki)

5-HT₃Receptor

782 nM (Ki)

体外研究
(In Vitro)

ML 10302 hydrochloride showsK_is of 1.07 nM and 782 nM for 5-HT₄receptor and 5-HT₃receptor, respectively, in binding assay^[1].

体内研究
(In Vivo)

ML 10302 hydrochloride (20 mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice^[3].

Animal Model:	8-weeks old adult male C57BL/6j wild-type mice (23-27 g)^[3]
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Subcutaneous injection
Result:	Significantly increased sAPPα level in the cortex.

分子量

349.25

Formula

C₁₅H₂₂Cl₂N₂O₃

CAS 号

186826-17-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.