您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > WAY-100135 dihydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
WAY-100135 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WAY-100135 dihydrochloride图片
CAS NO:149055-79-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
WAY-100135 dihydrochloride 是一种选择性的突触前和突触后5-HT1A受体拮抗剂,对大鼠海马 5-HT1A受体的IC50值为 34 nM。WAY-100135 dihydrochloride 具有潜在的抗精神病特性。
生物活性

WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic5-HT1Areceptor, with anIC50of 34 nM at the rat hippocampal 5-HT1Areceptor. WAY-100135 dihydrochloride has potential antipsychotic properties[1][2].

IC50& Target[1]

5-HT1AReceptor

34 nM (IC50)

体外研究
(In Vitro)

WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA2of 7.2[1].
WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons[2].

体内研究
(In Vivo)

WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats[1].
WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats[2].

分子量

468.46

Formula

C24H35Cl2N3O2

CAS 号

149055-79-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.