Aripiprazole monohydrate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

851220-85-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

OPC-14597 monohydrate

产品介绍

Aripiprazole (OPC-14597) monohydrate 是一种非典型抗精神病药，是一种有效、高亲和力的多巴胺D2受体部分激动剂。Aripiprazole monohydrate 在5-HT2B和5-HT2A受体上是一种反向激动剂，并在5-HT1A、5-HT2C、D3和D4受体上显示部分激动剂作用。Aripiprazole monohydrate 可用于精神分裂症和 COVID19 的研究。

生物活性

Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinitydopamine D2 receptorpartial agonist. Aripiprazole monohydrate is an inverse agonist at5-HT2Band5-HT2Areceptors and displays partial agonist actions at5-HT1A,5-HT2C,D3, andD4receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19^[1]^[2]^[3]^[4].

IC₅₀& Target

5-HT_1AReceptor

5-HT_2AReceptor

5-HT_2BReceptor

5-HT_2CReceptor

D₂Receptor

D₃Receptor

D₄Receptor

体外研究
(In Vitro)

Aripiprazole monohydrate potently activates D2 receptor-mediated inhibition of cAMP accumulation^[1].
Aripiprazole monohydrate shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine^[3].

体内研究
(In Vivo)

Aripiprazole monohydrate (0-3 mg/kg, IP, daily) shows some anxiolytic properties^[4].

Animal Model:	WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)^[4]
Dosage:	0, 0.3, 1, 3 mg/kg
Administration:	IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments
Result:	Showed some anxiolytic properties with the 1 mg/kg dose being the most active.

Clinical Trial

分子量

466.40

Formula

C₂₃H₂₉Cl₂N₃O₃

CAS 号

851220-85-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.