TIK-301

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TIK-301

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

118702-11-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

PD-6735
LY-156735

产品介绍

TIK-301 (PD-6735) 是一种氯化的褪黑激素衍生物，是一种有效的，高亲和力和口服活性的褪黑激素MT₁和MT₂受体激动剂，K_i分别为 0.081 nM 和 0.042 nM。TIK-301 还是一种5-HT_2B/5-HT_2C受体拮抗剂，具有抗抑郁作用。TIK-301 可用于睡眠障碍和其他昼夜节律障碍疾病的研究。

生物活性

TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally activemelatonin MT₁andMT₂receptorsagonist withK_is of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a5-HT_2B/5-HT_2Creceptorsantagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment^[1]^[2]^[3].

IC₅₀& Target

5-HT_2CReceptor

5-HT_2BReceptor

melatonin MT₁

0.081 nM (Ki)

melatonin MT₂

0.042 nM (Ki)

体内研究
(In Vivo)

In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake^[1]^[2].
The T_maxand half-life of TIK-301 is 1.1 hour and 1 hour, respectively^[1].

分子量

280.75

Formula

C₁₄H₁₇ClN₂O₂

CAS 号

118702-11-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.