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Ziprasidone mesylate trihydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ziprasidone mesylate trihydrate图片
CAS NO:199191-69-0
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
CP-88059 mesylate trihydrate
产品介绍
Ziprasidone (CP-88059) mesylate trihydrate 是一种具有口服活性的5-HT和多巴胺 (dopamine) 受体拮抗剂。Ziprasidone mesylate trihydrate 对大鼠D2(Ki=4.8 nM)、5-HT2A(Ki=0.42 nM) 和5-HT1A(Ki=3.4 nM) 有亲和作用。
生物活性

Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined5-HTanddopaminereceptor antagonist[1]. Ziprasidone mesylate trihydrate has affinities for Rat D2(Ki=4.8 nM), 5-HT2A(Ki=0.42 nM) and 5-HT1A(Ki=3.4 nM)[1].

IC50& Target

Rat 5-HT2Receptor

0.42 nM (Ki)

Rat 5-HT1AReceptor

3.4 nM (Ki)

Rat D2Receptor

4.8 nM (Ki)

体外研究
(In Vitro)

Ziprasidone mesylate trihydrate (0-500 nM, 150 seconds) blocks wild-type hERG current[2].

Cell Viability Assay

Cell Line:HEK-293 cells[2]
Concentration:0-500 nM
Incubation Time:150 seconds
Result:Blocked wild-type hERG current in a voltage- and concentration-dependent manner (IC50= 120 nm).
体内研究
(In Vivo)

Ziprasidone mesylate trihydrate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].

Animal Model:Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once daily; 7 weeks
Result:Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P< 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P< 0.001).
Clinical Trial
分子量

563.09

Formula

C22H31ClN4O7S2

CAS 号

199191-69-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.