CAS NO: | 21102-95-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a5-HT1Areceptor partial agonist[1][2]. | ||||
IC50& Target[1] |
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体外研究 (In Vitro) | BMY 7378 is selective for the alpha 1D-adrenoceptor subtype (pKi: hamster alpha 1b-adrenoceptor 6.2, human alpha 1b-adrenoceptor 7.2; bovine alpha 1c-adrenoceptor 6.1, human alpha 1c-adrenoceptor 6.6; rat alpha 1d-adrenoceptor 8.2, human alpha 1d-adrenoceptor 9.4) and has high affinity (pA2, 8.9) for rat aorta alpha 1-adrenoceptor[2]. | ||||
分子量 | 458.42 | ||||
Formula | C22H33Cl2N3O3 | ||||
CAS 号 | 21102-95-4 | ||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |