CAS NO: | 269718-84-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Pardoprunox (SLV-308) is a partialdopamine D2andD3 receptorpartial agonist and aserotonin 5-HT1A receptoragonist, withpEC50s of 8, 9.2, and 6.3, respectively[1]. | |||
IC50& Target |
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体外研究 (In Vitro) | Pardoprunox (SLV-308) acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0). Pardoprunox acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3)[1]. | |||
Clinical Trial | ||||
分子量 | 233.27 | |||
Formula | C12H15N3O2 | |||
CAS 号 | 269718-84-5 | |||
中文名称 | 帕多芦诺 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |