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Pardoprunox
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pardoprunox图片
CAS NO:269718-84-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
SLV-308
DU-126891
产品介绍
Pardoprunox (SLV-308) 是多巴胺受体D2D3部分激动剂和5-HT1A激动剂,pEC50分别为 8, 9.2, 6.3。
生物活性

Pardoprunox (SLV-308) is a partialdopamine D2andD3 receptorpartial agonist and aserotonin 5-HT1A receptoragonist, withpEC50s of 8, 9.2, and 6.3, respectively[1].

IC50& Target

5-HT1AReceptor

6.3 (pEC50)

D2Receptor

8 (pEC50)

D3Receptor

9.2 (pEC50)

体外研究
(In Vitro)

Pardoprunox (SLV-308) acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0). Pardoprunox acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3)[1].

Clinical Trial
分子量

233.27

Formula

C12H15N3O2

CAS 号

269718-84-5

中文名称

帕多芦诺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.