Propranolol-d7 (ring-d7) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselectiveβ-adrenergic receptor (βAR)antagonist, has high affinity for the β1AR and β2AR withK_ivalues of 1.8 nM and 0.8 nM, respectively^[1]. Propranolol hydrochloride inhibits [³H]-DHA binding to rat brain membrane preparation with anIC₅₀of 12 nM^[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

266.39

Solid

C₁₆H₁₄D₇NO₂

344298-99-3

盐酸普萘洛尔 d7

Room temperature in continental US; may vary elsewhere.