Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selectiveβ/α-1blocker^[1]. Carvedilol phosphate hemihydrate inhibitslipid peroxidationwith an IC₅₀of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol phosphate hemihydrate is anautophagyinducer that inhibits theNLRP3inflammasome^[3].

β/α-1 adrenergic receptor^[1]
IC50: 5 μM (lipid peroxidation)^[2]
Autophagy^[3]

Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC₅₀of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC₅₀of 25 μM^[2].

513.48

C₂₄H₂₆N₂O₄. H₃PO₄.1/2H₂O

610309-89-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.