1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, aquinolonealkaloid, is adiacylglycerolacyltransferaseinhibitor andangiotensin II receptorblocker, withIC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pyloriactivity with the MIC of 10 μg/mL^[1][2][3].

IC50: 20.1 μM (diacylglycerol acyltransferase)^[3], 34.1 μM (angiotensin II receptor)^[2]

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows anti-Helicobacter pylori activity, with the MIC of 10 μg/mL, and has no effect on Helicobacter pylori urease activity at the concentration of 300 μg/mL^[1].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-500 μM) shows a dose-dependent diacylglycerol acyltransferase (DGAT) inhibition, with an IC₅₀of 20.1 μM^[3].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-20 μM) inhibits leukotriene biosynthesis in human polymorphonuclear granulocytes, with an IC₅₀of 10.1 μM^[4].

337.50

C₂₃H₃₁NO

120693-53-0

• Alkaloids
• Quinoline Alkaloids

• Plants
• Rutaceae
• Evodia rutaecarpa(Juss.) Benth.

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.