CAS NO: | 168273-06-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Rimonabant (SR141716) is a highly potent, brain penetrated and selective centralcannabinoid receptor(CB1)antagonist with aKiof 1.8 nM. Rimonabant (SR141716) also inhibitsMycobacterialmembrane protein Large 3 (MMPL3). | |
IC50& Target[1] |
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体外研究 (In Vitro) | Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant[2]. | |
体内研究 (In Vivo) | Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant[1]. | |
Clinical Trial | ||
分子量 | 463.79 | |
Formula | C22H21Cl3N4O | |
CAS 号 | 168273-06-1 | |
中文名称 | 利莫那班 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |