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Rimonabant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rimonabant图片
CAS NO:168273-06-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
利莫那班
SR141716
产品介绍
Rimonabant (SR141716) 是中心大麻素受体 1(CB1)高效的、选择性的、能透过血脑屏障的拮抗剂, Ki值为 1.8 nM。Rimonabant (SR141716) 也能够抑制分枝杆菌膜蛋白3(MMPL3)
生物活性

Rimonabant (SR141716) is a highly potent, brain penetrated and selective centralcannabinoid receptor(CB1)antagonist with aKiof 1.8 nM. Rimonabant (SR141716) also inhibitsMycobacterialmembrane protein Large 3 (MMPL3).

IC50& Target[1]

CB1

1.8 nM (Ki)

体外研究
(In Vitro)

Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant[2].
Rimonabant itself (10-12-10-3M, 12 concentrations) inhibits the basal binding of [35S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC50of 4.7±0.2 (IC50= 20 μM) and a maximal inhibition of 48±2%[3].

体内研究
(In Vivo)

Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant[1].
Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors[4].

Clinical Trial
分子量

463.79

Formula

C22H21Cl3N4O

CAS 号

168273-06-1

中文名称

利莫那班

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.