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BGC 20-761
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BGC 20-761图片
CAS NO:17375-63-2
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
BGC 20-761 是一种选择性 5-HT6 和多巴胺受体拮抗剂（人受体 Ki 值：5-HT6 (20 nM)、5-HT2A (69 nM)、D2 (140 nM)）。
Cas No.17375-63-2
化学名2-(5-methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine
Canonical SMILESCOC1=CC2=C(NC(C3=CC=CC=C3)=C2CCN(C)C)C=C1
分子式C19H22N2O
分子量294.39
溶解度<14.72mg/ml in ethanol;<29.44mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BGC20-761 is a selective and high affinity antagonist of 5-HTC.

The 5-HT6 receptor, a G protein-coupled receptor (GPCR), is a subtype of 5-HT receptor which binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). This protein is expressed almost exclusively in the brain and mediates excitatory neurotransmission.

In cellular level, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine) was shown to selectively blocked 5-HTC.

BGC20-761 was used to study the difference in drug- induced effects in memory consolidation in young and mature rats and human. In young mice, BGC20-761 treatment at doses of 5 mg/kg and 10 mg/kg i.p, dose-dependently reversed a deficit of social recognition induced by scopolamine, an anticholinergic drug that impairs memory at dosage of 0.4 mg/kg i.p. In mature rats (6 months), recognition of the novel object was improved following administration of BGC20-761. The difference in effects of BGC20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges 1.

Reference:
1.  Mitchell ES, Hoplight BJ, Lear SP, et al. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology. 2006;50(4):412-420.