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NPS ALX Compound 4a dihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NPS ALX Compound 4a dihydrochloride图片
CAS NO:299433-10-6
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
NPS ALX Compound 4a dihydrochloride 是一种有效的选择性 5-hydroxytryptamine6 (5-HT6) 受体拮抗剂，IC50 为 7.2 nM，Ki 为 0.2 nM。
Cas No.299433-10-6
化学名(S)-2-(1-(naphthalen-1-ylsulfonyl)-1H-indol-6-yl)octahydropyrrolo[1,2-a]pyrazine dihydrochloride
Canonical SMILESO=S(N1C2=C(C=C1)C=CC(N3C[C@H]4N(CC3)CCC4)=C2)(C5=CC=CC6=CC=CC=C56)=O.Cl.Cl
分子式C25H25N3O2S.2HCl
分子量504.47
溶解度<50.45mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM, which also has a great binding affinity with Ki of 0.2 nM[1].

References:
[1]. Isaac M, et al. 6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindolesderivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1719-21.