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MRS 1754
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MRS 1754图片
CAS NO:264622-58-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议

产品介绍
MRS 1754 是一种选择性拮抗 A2B 腺苷受体的放射性配体，对人和大鼠的 A1 和 A3 受体的亲和力非常低。
Cas No.264622-58-4
化学名N-(4-cyanophenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetamide
Canonical SMILESO=C(N(C1=O)CCC)N(CCC)C2=C1NC(C(C=C3)=CC=C3OCC(NC4=CC=C(C#N)C=C4)=O)=N2
分子式C26H26N6O4
分子量486.52
溶解度15 mg/mL in DMSO，insoluble 0.1 mg/mL in Water
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1].

The most potent displacer of [3H]MRS 1754 binding is MRS 1754. The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM[1].

References:
[1]. Ji X, et al. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 Mar 15;61(6):657-63.